What are the key principles of early sepsis management?

Hour-1 bundle: measure lactate, obtain blood cultures before antibiotics, administer broad-spectrum antibiotics, begin 30mL/kg crystalloid for hypotension or lactate ≥4 mmol/L. Vasopressors (norepinephrine first-line) if MAP <65 after fluid resuscitation. Source control within 6-12 hours. De-escalate antibiotics based on culture results. Steroids for refractory shock. Avoid excessive fluid after initial resuscitation.