What is the treatment approach for rheumatoid arthritis?

Early DMARD initiation within 3 months of symptom onset. Methotrexate is first-line conventional DMARD (csDMARD). Short-term glucocorticoids for bridging. Treat-to-target: adjust therapy every 3 months until remission or low disease activity. If inadequate response to methotrexate, add or switch to biologic (TNF inhibitors, IL-6 inhibitors, JAK inhibitors) or other csDMARDs. Consider combination csDMARD therapy. Regular monitoring for disease activity and drug toxicity.