How should generalized anxiety disorder be treated?

CBT is first-line and most effective long-term. SSRIs (sertraline, escitalopram, paroxetine) and SNRIs (venlafaxine, duloxetine) are first-line pharmacotherapy. Buspirone is an alternative. Benzodiazepines only for short-term or adjunctive use—avoid long-term due to dependence. Pregabalin used in some regions. Combination therapy for moderate-severe GAD. Allow 4-8 weeks for medication response. Continue 12+ months after remission.