What is the approach to acute kidney injury management?

Identify prerenal, intrinsic, or postrenal cause through history, examination, urinalysis, and imaging. Optimize volume status—fluid resuscitation for hypovolemia, diuresis for overload. Discontinue nephrotoxins (NSAIDs, aminoglycosides, contrast when possible). Adjust medication dosing. Monitor for RRT indications: refractory hyperkalemia, acidosis, uremia symptoms, volume overload. No proven pharmacologic therapy to hasten recovery. Follow creatinine trajectory and urine output.